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Search Results for " Diacylglycerol acyltransferase "

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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T11037	Diacylglycerol acyltransferase inhibitor-1		Others
	Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1.		Others
T13373	YM17E		Acyltransferase , AChR
			Acyltransferase , AChR
T12767	RP 70676		Acyltransferase
			Acyltransferase
T15109	DGAT1-IN-1		Transferase
	DGAT1-IN-1 is a potent inhibitor of diacylglycerol O- acyltransferase type 1(DGAT1, IC50 of < 10 nM).		Transferase
T9711	OGT-IN-2		Others
	OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1].		Others
T8314	RP-64477	RP64477	Acyltransferase
	RP-64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor.		Acyltransferase
T12425	PF-06424439 methanesulfonate		Acyltransferase , Transferase
	PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inh...		Acyltransferase , Transferase
T6937	PF-04620110	PF04620110,PF 04620110	Acyltransferase , Transferase
	PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.		Acyltransferase , Transferase
T8236	RHC 80267	U-57908	Others , Phospholipase , COX , Acyltransferase , AChR
	RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)		Others , Phospholipase , COX , Acyltransferase , AChR
T10035	10,12-Tricosadiynoic acid	TDA,TCDA	Acyltransferase
	10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me...		Acyltransferase
T23521	VULM 1457		Acyltransferase
	VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of...		Acyltransferase
T16409	OSMI-1		Others , Acyltransferase
	OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.		Others , Acyltransferase
T23550	YM-750	YM 750	Acyltransferase
	YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholest...		Acyltransferase
T4681	T863	DGAT-3,DGAT-1 inhibitor	Acyltransferase , Transferase
	T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis...		Acyltransferase , Transferase
T11733	K-604 dihydrochloride		Acyltransferase
	K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM.		Acyltransferase
T22665	PD 128042	CI 976	Acyltransferase
	PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multi...		Acyltransferase
T2753	Avasimibe	PD-148515,CI-1011	P450 , Acyltransferase
	Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz...		P450 , Acyltransferase
T15247	ESI-05	NSC 116966	cAMP
	ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.		cAMP
T6365	A 922500	A922500,DGAT-1 Inhibitor 4a	Acyltransferase , Transferase
	A 922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.		Acyltransferase , Transferase
T12225L	Nevanimibe hydrochloride	PD-132301 hydrochloride,ATR101 hydrochloride	Apoptosis , Acyltransferase
	Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).		Apoptosis , Acyltransferase
T12426	PF-06424439		Acyltransferase , Transferase
			Acyltransferase , Transferase
T14375	AZD3988		Transferase
	AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity.		Transferase
T11827	Pradigastat	ANJ908,LCQ908-NXA,LCQ908A,LCQ-908	Transferase
	Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes.		Transferase
T9186	Ervogastat	PF-06865571	Transferase
	Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).		Transferase
T11016	DGAT-1 inhibitor 2		Transferase
	DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride s...		Transferase
T24128	H2-005	H2 005
	H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
T70160	PF-06427878
	PF-06427878 is an orally active, potent and selective diacylglycerol acyltransferase 2 inhibitor.
T24127	H2-003	H2003
	H2-003 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
T27692	JNJ-DGAT2-B	JNJDGAT2B,JNJ DGAT2 B
	JNJ-DGAT2-B is a selective inhibitor of Diacylglycerol acyltransferase 2.
T79764	PF-07202954		Acyltransferase
	PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against human DGAT2 and effectively reduces liver triglyceride content i...		Acyltransferase
T37691	Phosphatidic Acids (egg) (ammonium salt)
	Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis. It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple rout...
T71886	ALN29882
	ALN29882 is a glycerolipid, that is located at the plasma membrane. It is made up of two fatty acid chains that are covalently attached to a single glycerol molecule with the help of an ester linkage. 18:1 DG has been u...

Compounds

Diacylglycerol acyltransferase inhibitor-1

Target: Acyltransferase, AChR

RP 70676

T12767

Synonym:

Target: Acyltransferase

Target: Acyltransferase

PF-06424439 methanesulfonate

T12425

Synonym:

Target: Acyltransferase, Transferase

PF-04620110

T6937

Synonym: PF04620110,PF 04620110

Target: Acyltransferase, Transferase

RHC 80267

T8236

Synonym: U-57908

Target: Others, Phospholipase, COX, Acyltransferase, AChR

10,12-Tricosadiynoic acid

T10035

Synonym: TDA,TCDA

Target: Acyltransferase

VULM 1457

T23521

Synonym:

Target: Acyltransferase

OSMI-1

T16409

Synonym:

Target: Others, Acyltransferase

YM-750

T23550

Synonym: YM 750

Target: Acyltransferase

T863

T4681

Synonym: DGAT-3,DGAT-1 inhibitor

Target: Acyltransferase, Transferase

K-604 dihydrochloride

T11733

Synonym:

Target: Acyltransferase

PD 128042

T22665

Synonym: CI 976

Target: Acyltransferase

Avasimibe

T2753

Synonym: PD-148515,CI-1011

Target: P450, Acyltransferase

Synonym: A922500,DGAT-1 Inhibitor 4a

Target: Acyltransferase, Transferase

Nevanimibe hydrochloride

T12225L

Synonym: PD-132301 hydrochloride,ATR101 hydrochloride

Target: Apoptosis, Acyltransferase

PF-06424439

T12426

Synonym:

Target: Acyltransferase, Transferase

Synonym: ANJ908,LCQ908-NXA,LCQ908A,LCQ-908

Synonym: JNJDGAT2B,JNJ DGAT2 B

Target: Acyltransferase

Phosphatidic Acids (egg) (ammonium salt)

カタログ番号	製品名	別名	ターゲット
TN1691	Glabrol		P450 , NF-κB , NO Synthase , Acyltransferase
	Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.		P450 , NF-κB , NO Synthase , Acyltransferase
T3342	Xanthohumol		Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV
	Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ...
T5544	2-Furoic acid	Furan-2-carboxylic acid	Anti-infection , ATP Citrate Lyase , Endogenous Metabolite , Acyltransferase
	2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.
T69446	Cochlioquinone A
	Cochlioquinone A is an inhibitor of diacylglycerol kinase (DGK) and diacylglycerol acyltransferase (DGAT). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma and has also been shown to ...
TN3428	Aphadilactone C		Others
	Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, ...		Others
TN1843	Kushenol K		PDE , HSV
	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus t...		PDE , HSV
T37690	Phenylpyropene A
	Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM)....
TN3255	7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone		Others
	7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone shows diacylglycerol acyltransferase (DGAT)1 inhibition with IC(50) values of 47.0 microM (for rat liver microsomes) and 160.7 m...		Others
T75697	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, exhibits IC50 values of 20.1 μM and 34.1 μM, respectively. Additionally, it demonstr...

天然物製品

Glabrol

TN1691

Synonym:

Target: P450, NF-κB, NO Synthase, Acyltransferase

Xanthohumol

T3342

Synonym:

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

2-Furoic acid

T5544

Synonym: Furan-2-carboxylic acid

Target: Anti-infection, ATP Citrate Lyase, Endogenous Metabolite, Acyltransferase

7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone

TN3255

Synonym:

Target: Others

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

T75697

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-03003	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO)	Mycobacterium tuberculosis	E. coli
	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.6 kDa and the accession number is P9WQP2.
TMPH-03007	Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	E. coli
	Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.1 kDa and the accession number is P9WQN8.
TMPH-03004	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	E. coli
	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.1 kDa and the accession number is P9WQP2.
TMPH-03006	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	P. pastoris (Yeast)
	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 32.7 kDa and the accession number is P9WQP0.
TMPH-03005	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His)	Mycobacterium tuberculosis	E. coli
	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.2 kDa and the accession number is P9WQP0.